Wellbutrin May Cause Infant Heart Defects or Cleft Palate

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Wellbutrin is commonly prescribed to women who are or may become pregnant for several reasons, including as an antidepressant SSRI aid and as a smoking cessation pill. Regardless of the reason, women who take this drug may experience a greater than average risk of infant child birth defects, including but not limited to heart defects, cleft palate, cleft lip, skeletal deformations and more. If your child experienced such a horrific side effect, please call us today for a free case evaluation on how we can help.

The Problem

Our firm is offering free nationwide case evaluations to families whose children were diagnosed with medical conditions at birth or shortly therafter when the mother ingested Wellbutrin or Bupropion during pregnancy. Specific birth defects include cardiac malformations (ASD, VSD, Left Hypoplastic Heart Syndrome, coarctation of the aorta, Tricuspid or Pulmonary Atresia, Pulmonary Stenosis, transposition of the great vessels or any other heart defect), neural tube defect, craniosynostosis, cleft lip, cleft palate, skeletal deformations, and club foot.

About Wellbutrin

Wellbutrin is an antidepressant drug prescribed to treat major depressive disorder, also called major depression and clinical depression, and seasonal affective disorder, a type of depression involving adverse side effects that occur each year during the same season. First approved by the FDA in 1985, bupropion hydrochloride was available for several years only under the brand name Wellbutrin. In 1996, the FDA approved a sustained-release tablet of this drug called Wellbutrin SR and, in 2003, approved an extended-release tablet known as Wellbutrin XL.

Wellbutrin carries a Pregnancy Category C classification, meaning that animal reproduction studies have shown an adverse effect on the fetus but that no adequate or well-controlled studies in humans have been performed.

Wellbutrin has been linked to congenital heart defects. Congenital heart defects affect approximately 40,000 babies each year, and one of the primary known causes of such birth defects is the ingestion of teratogenic drugs during pregnancy. A teratogen is a drug or other substance capable of interfering with the development of a fetus that can ultimately result in serious birth defects.

Scientific Study

A 2010 case-control study published in the American Journal of Obstetrics and Gynecology suggests that women who take Wellbutrin during early pregnancy may run a greater risk for having a baby born with a heart birth defect. This study identifies a positive association between early pregnancy Wellbutrin use and left outflow tract heart birth defects. Researchers caution that the findings of this study are not conclusive and that further research is needed to confirm the findings. Women taking Wellbutrin who are planning to become pregnant should speak with their doctors about the potential side effects and alternative options.

Getting Help

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